Collagen synthesis, inhibitors

Yamada H, Tajima S, NishikawaT, Murad S, Pinnell SR. Tranilast, a selective inhibitor of collagen synthesis in human skin fibroblasts. Journal of Biochemistry 1994, 116,... 

Czuwara-Ladykowska J, Makiela B, Smith EA, Trojanowska M, Rudnicka L. The inhibitory effects of camptothecin, a topoisomerase I inhibitor, on collagen synthesis in fibroblasts from patients with systemic sclerosis. Arthritis Research 2001, 3,311-318. 

Nwogu Jl, Geenen D, Bean M, Brenner MC, Huang X, Buttrick PM. Inhibition of collagen synthesis with prolyl 4-hydroxylase inhibitor improves left ventricular function and alters the pattern of left ventricular dilatation after myocardial infarction. Circulation 2001 104 2216-2221. 

Use of aldose reductase inhibitors prevents the loss of pericytes in animals maintained on high-galactose diets (Robinson et al., 1989). Also, in streptozocin-diabetic or fructose-fed rats the development of retinopathic changes was prevented by aldose reductase inhibitors (Kojima et al., 1985). In contrast, collagen synthesis by retinal pericytes was unaffected (Li et al., 1985). 

Yamada, H.,Tajima, S., Nishikawa,T.,Murad, S., and Pinnell, S Jl. (1994) TranUast, a Selective Inhibitor of Collagen Synthesis in Human Skin Fibroblasts, J. Biochem. 116,892-897. 

Uses Antioxidant in cosmetics whitening agent for skin lightening creams collagen synthesis promoter lipid peroxidation inhibitor... 

The other side of the extracellular matrix balance is the degradation of proteins by matrix metaUoproteinases (MMPs) and their control by specific tissue inhibitors. The fibrosis that results from chronic inflammation is accompanied not only by increase in collagen synthesis but also by increase in the enzymes that control degradation (46). These enzymes are involved in the pathogenesis of tumors, and inhibitors to MMPs have been labeled with F (56) and (57) for oncology imaging with PET. Unfortunately, the localization of markers developed so far in tumors appeared to be related to nonspecific binding (57). 

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