Collagen fibre deposition

Feverfew extract was shown to inhibit deposition, aggregate formation and spreading of platelets on collagen fibres [54]. Changes in membrane-cytoskeletal interaction leading to a change in expression of membrane receptors involved in these processes may explain this result. Feverfew extract was further able to protect the endothelial monolayer in rabbit aortas from perfusion injury and some reversible increase in cAMP levels in the aorta segments was found [55]. 

In the second stage, as the needle-like calcium phosphate deposits radially grow out of the vesicles, the surrounding collagen fibres become mineralized. 

A hyperimmune reaction may also have been involved in a case where retroperitoneal fibrosis developed. Immune fluorescence techniques demonstrated deposits of IgG, IgM and IgA on the collagen fibres there were no signs of vasculitis or general vascular disease. The Coombs test was positive (53 -). 

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