Colistin polymyxin chemical structure

Fig. 3.9 Chemical structures of colistin, polymyxin, rifaximin, rifamycin SV, novobiocin, and tiamulin.

Figure 14.10 Poiymyxin, chemical structures (a) Polymyxin E (colistin) (b) Polymyxin B (Polymyxin B R=FI is polymyxin B1, R=CFl3 is polymyxin B2).

Suzuki T, Hayashi K, Fujikawa K, Tsukamoto K (1965) The chemical structure of polymyxin E the identities of polymyxin El with colistin A and polymyxin E2 with colistin. J Biol Chem 57 226-227... 

Suzuki, T., K. Hayashi, K. Fujikawa, and K. Tsukamoto The chemical structure of polymyxin E The identities of polymyxin E with colistin A and of polymyxin Eg with colistin B. J. Biochem. (Japan) 57, 226 (1965). 

Chemically, colistin is a polypeptide, reported by Suzuki (1 al.. whose major component is colistin A. They pro-pt sed the structure shown below for colistin A. which differs hnm polymyxin B only by the substitution of n-leucine for isphcnylalanine as one of the amino acid fragments in the. jclic portion of the structure. Wilkinson and Lowe have c lTToboraied the structure and have shown that colistin A is iihiiiul with polymyxin Ej. 

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