Colestipol NSAIDs

T Effects W/ antihypertensives, cliazoxicle, nitrates, EtOH T effects OF ACEIs, Li T risk of hypokalemia W/ amphotericin B, corticosteroids, mezlocillin, piperacillin, ticarcillin effects W/ cholestyramine, colestipol, NSAIDs EMS Monitor ECG for hypokalemia (flattened T waves) T risk of photosensitivity Rxns use caution w/ other diuretics, may T risk of electrolyte imbalances and dehydration may affect glucose (hyperglycemia) OD May cause dehydration, hypotension, drowsiness, headache, and fatigue symptomatic and supportive, do not do anything that would force greater fluid loss (ie, induce V)... 

Drugs that may affect beta blockers include aluminum salts, barbiturates, calcium salts, cholestyramine, cimetidine, colestipol, diphenhydramine, hydroxychloroquine, NSAIDs, penicillins (ampicillin), rifampin, salicylates, SSRIs, sulfinpyrazole, calcium blockers, oral contraceptives, flecainide, haloperidol, hydralazine, loop diuretics,... 

Drugs that affect NSAIDs include the following Bisphosphonates, cholestyramine, cimetidine, colestipol, cyclosporine, diflunisal, DMSO, fluconazole, ketoconazole, phenobarbital, phenylbutazone, probenecid, rifampin, ritonavir, salicylates, sucralfate. 

The studies of simultaneous oral use suggest that the anion exchange resin colestyramine, and to a lesser extent colestipol, bind anionic NSAIDs (e.g. diclofenac) in the gut, so reducing their absorption. The studies showing reduced plasma levels when colestyramine was given after intravenous oxicams or separated by at least 3 hours from some oral NSAIDs, suggest that colestyramine can reduce the enterohepatic recirculahon of these drugs. 

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