Warfarin Colesevelam

Absorption of certain drugs, including those with neutral or cationic charge as well as anions, may be impaired by the resins. These include digitalis glycosides, thiazides, warfarin, tetracycline, thyroxine, iron salts, pravastatin, fluvastatin, folic acid, phenylbutazone, aspirin, and ascorbic acid. Any additional medication (except niacin) should be given 1 hour before or at least 2 hours after the resin to ensure adequate absorption. Colesevelam does not bind digoxin, warfarin, or reductase inhibitors. 

Any additional medication (except niacin) should be given 1 hour before or at least 2 hours after the resin to ensure adequate absorption. Colesevelam does not bind digoxin, warfarin, or reductase inhibitors. 

Warfilone warfarin podophyllotoxin podophyllotoxin ceftazidime dimenhydrinate colesevelam bupropion chloral hydrate atovaquone phenylpropanolamine danazol stanozolol erythromycin erythromycin guanabenz... 

Colesevelam appears to be less likely to interfere with the absorption of concurrently administered drugs. No significant decreases in absorption were seen when colesevelam was coadministered with either digoxin, lovastatin, warfarin, metoprolol, quinidine, or valproic acid. Because of potential interactions, especially for drugs with a low therapeutic index, the administration of drugs that have not been directly studied in combination with colesevelam should be spaced accordingly, as described above tor cholestryamine and colestipol (7,15). 

The anticoagulant effects of phenprocoumon and warfarin can be reduced by colestyramine, especially if the coumarin is given at the same time. An isolated report describes unexpected sensitivity to warfarin in a patient taking colestyramine, which was attributed to a possible reduction in vitamin K absorption with colestyramine. Colestipol did not alter the absorption or effect of phenprocoumon or warfarin and colesevelam did not alter the pharmacokinetics of warfarin. 

Colesevelam 4.5 g had no effect on the pharmacokinetics of warfarin 10 mg in a single-dose study in 24 healthy subjects. ... 

No special precautions appear necessary if warfarin or phenprocoumon and colestipol or colesevelam are given concurrently. 

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