Restenosis colchicine

Inflammatory response after stent implantation plays an important role in the cascade of neointimal formation. A positive correlation between inflammatory reaction and restenosis has been observed (16). Perivasculitis caused by stent deployment also participates in the neointimal formation (17). Corticosteroids, as an anti-inflammatory agent, have been evaluated. Methylprednisolone (MP)-loaded stents with different doses showed a positive dose-related effect on neointimal hyperplasia (18). Furthermore, MP-coated stents showed decreased macrophages at the stented sites (19). In clinic, dexamethasone-coated stents showed an inhibitive effect on neointimal hyperplasia in selected patients (20), although no beneficial effect was observed in a randomized trial compared to bare stents (21). For other type of drugs with anti-inflammatory characteristics, such as ibuprofen, colchicine, aton/astatin, and probucol, no favorable effects on neointimal hyperplasia were observed (18,22,23). 

Colchicine Inhibits microtubule assembly and cell division Rabbit femoral artery Local infusion of drug-containing biodegradable microparticles Did not reduce restenosis Induced toxicity to adjacent musculature (102)... 

O Keefe JH Jr, McCallister BD, Bateman TM, Kuhnlein DL, Ligon RW, Hartzler GO. Ineffectiveness of colchicine for the prevention of restenosis after coronary angioplasty, J Am Coll Cardiol 1992 I 9(7) I 597-1 600. 

Gradus-Pizlo I, Wilensky RL, March KL, et al. Local delivery of biodegradable microparticles containing colchicine or a colchicine analogue effects on restenosis and implications for catheter-based drug delivery. J Am Coll Cardiol 1995 26(6) 1549-1557. 

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