Coffee consumption, benefits

Chronic overdose. Excessive prolonged consumption of caffeine causes anxiety, restlessness, tremors, insomnia headache, cardiac extrasystoles and confusion diarrhoea may occur with coffee and constipation with tea. The cause can easily be overlooked if specific enquiry into habits is not made including children regarding cola drinks. Of coffee drinkers, up to 25% who complain of anxiety may benefit from reduction of caffeine intake. An adult heavy user may be defined as one who takes more than 300 mg caffeine/day, i.e. 4 cups of 150 ml of brewed coffee, each containing 80 20 mg caffeine per cup or 5 cups (60 20) of instant coffee. The equivalent for tea would be 10 cups at approximately 30 mg caffeine per cup and of cola drinks about 2.01. Plainly, caffeine drinks brewed to personal taste of consumer or vendor must have an extremely variable concentration according to source of coffee or tea, amormt used, method and duration of brewing. There is also great individual variation in the effect of coffee both between individuals and sometimes in the same individual at different times of life (see Sleep, above). 

I Administration. Even under optimal conditions, all bisphosphonates are poorly absorbed (bioavailabihty = 1% to 5%). Bisphosphonates must be administered carefully to optimize the chnical benefit and minimize the risk of adverse G1 effects. Each oral tablet should be taken with at least 4 ounces of plain tap water (not coffee, juice, mineral water, or milk) at least 30 minutes before consuming any food or any other supplement or medication. The weekly oral solution needs to be taken with only 2 ounces of water. The patient should remain upright (either sitting or standing) for at least 30 minutes after bisphosphonate administration. When calcium and vitamin D dietary consumption are insufficient, supplementation is needed to ensme the beneficial effects of bisphosphonates. 

---