Cobra motif

The Cobra motif (Fig. 27) is characterized by the bending of the side chain such that its dihydropyran ring lies over the center of the face of the macrolide ring. All but one of the conformers of this class possess unreasonably high energies according to... 

As has been described under the subheading NAMFIS Deconvolution Analysis above, NAMFIS analysis cannot guarantee that a particular single conformation is present in the solution ensemble. Still, the method ensures that very similar con-formers representative of the same family exit in the ensemble. In the case of laulimalide, it can be argued whether the low populated Concave and Cobra motifs may... 

---