CMV infection ganciclovir

The spectrum of adverse reactions reported in 120 immunocompromised pediatric clinical trial participants with serious CMV infections receiving IV ganciclovir were similar to those reported in adults. Granulocytopenia (17%) and thrombocytopenia (10%) were most commonly reported. 

Intravenous ganciclovir is indicated for the treatment of CMV retinitis in immunocompromised individuals, including those with AIDS, and for the prevention of CMV infection in organ transplant recipients. Oral ganciclovir is less effective than the intravenous preparation but carries a lower risk of adverse effects. It is... 

Other CMV infections IV Initially, 10mg/kg/dayindivideddosesql2hfor 14-21 days, then 5 mg/kg/day as a single daily dose. Maintenance 1000 mg 3 times a day or 500 mg q3h (6 times a day). Intravitreal implant 1 implant q6-9mo plus oral ganciclovir. Dosage in renal impairment Dosage and frequency are modified based on creatinine clearance. 

Six infants with cholestasis (aged 3-16 weeks) and signs of CMV infection were given intravenous ganciclovir for 3-7 weeks (431). One patient with septo-optic dysplasia and hypothyroidism had episodes of symptomatic hypoglycemia during treatment, which was withdrawn. 

Ganciclovir Cytovene Treatment of CMV retinitis in immunocompromised patients also used to prevent CMV infection after organ transplants... 

Antiviral Efficacy and Clinical Use. Fomivirsen (Vitravene) is injected into the vitreous humour to treat CMV infection in the eye.42 This drug is often used to treat ocular CMV infections that are resistant to more traditional agents such as ganciclovir or fos-carnet. 

The lack of effect of available nucleoside analogs on cytomegalovirus (CMV) infection led to the synthesis of the acyclovir analog, ganciclovir [gan SYE kloe ver] (9-[(1,3-dihydroxy-2-propoxy)methyl]guanine, DHPG). It is currently available for treatment of cytomegalic retinitis in immunocompromised patients. 

J.) Ganciclovir This is a guanosine derivative exhibiting a good action profile in HBV, EBV, CMV and VZV infection. Ganciclovir triphosphate inhibits virus replication. The half-life is about 4 hours. Elimination is via the kidneys. Only a minor fraction of this substance is absorbed after oral administration application (e.g. in CMV infection) is usually intravenous (10 mg/kg BW/ day). It has severe toxic side effects. Ganciclovir was... 

Some other uncommon complications include macular edema, vitreous hemorrhage, hypotony, cataract (Fig. 6), temporary reduced vision secondary to astigmatism, implant malposition, and retinal detachment, which is more likely if the CMV infection involves over 25% of the retina (100). Lim and colleagues evaluated a series of 110 ganciclovir implant procedures and noted posterior segment complications in 12% (111). Some of these eyes had undergone multiple prior implant procedures and... 

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