Clozapine salivary glands

Hypersalivation is a common adverse effect of clozapine (170), which has been estimated to occur in 10-23% of patients (SEDA-20, 49). Salivary gland swelling has been reported in patients treated with clozapine (SEDA-20, 49 171). 

In 12 patients clonidine 50-100 micrograms/day relieved clozapine-induced sialorrhea, with good results in three and partial results in eight (178). Theoretically, the reduction in sialorrhea with clonidine could have been due to reduced plasma noradrenaline concentrations, resulting in less stimulation of unopposed p-adrenoceptors in the salivary glands. 

Salivary Glands A case of xmilateral parotid gland swelling in a 35-year-old female following clozapine initiation and which resolved on discontinuation is reported [129 ]. Another case of a 58-year-old male who developed bilateral parotid gland swelling with clozapine responded to treatment with benztropine and terazosin and continued with clozapine [130 ]. 

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See also in sourсe #XX -- [ ]

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