Clotting Time on Concentration and pH

The clotting time decreases with increasing pH in the range from 6.2 to 7.2, as shown in Fig. 21 for several fibrinogen concentrations. 

Clotting time plotted against pH, at ionic strength 0.30 and thrombin 1 unit/cc. Fibrinogen concentrations in g./liter 1, 24 2, 12 3, 6 4, 3 6, 1.5. From Ferry and Morrison (1947a). 

Clotting time plotted against ionic strength, for fibrinogen concentra tion 5 g./liter and pH 6.3. Thrombin concentrations in unit/cc. 1,0.1 2, 0.5 3,1.0 4, 2.0 5, 5.0. From Ferry and Morrison (1947a). 

---