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Isoniazid Clotiazepam

Ochs HR, Greenblatt DJ, Verburg-Ochs B, Harmatz JS, Grehl H. Disposition of clotiazepam influence of age, sex, oral contraceptives, cimetidine, isoniazid and ethanol. EurJ Clin Pharmacol 9%A) 26, 55-9. [Pg.729]

Isoniazid reduces the clearance of both diazepam and triazolam. Some increase in their effects would be expected. No interaction occurs with oxazepam or clotiazepam. [Pg.729]

Information is limited but the interactions appear to be established. Their clinical importance is uncertain but be alert for the need to decrease the dosages of diazepam and triazolam if isoniazid is started. There seems to be no direct information about other benzodiazepines, but those undergoing high first-pass extraction and/or liver microsomal metabolism may interact similarly. Oxazepam and clotiazepam appear not to interact. [Pg.730]


See also in sourсe #XX -- [ Pg.729 ]




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