Clotiazepam

BZDs that undergo a high first-pass effect before reaching the systemic circulation (e.g., brotizolam, clotiazepam, midazolam, and triazolam) may have short-lived but active metabolites. 

Oral contraceptives alter the metabolism of some benzodiazepines that undergo oxidation (chlordiazepoxide, alprazolam, diazepam) or nitroreduction (nitrazepam) (334). Oral contraceptives inhibit enzyme activity and reduce the clearances of these drugs. There is nevertheless no evidence that these interactions are of clinical importance. For other benzodiazepines that undergo oxidative metabolism, such as bromazepam and clotiazepam, no change has ever been found in oral contraceptive users. 

Cloxazolam, nitrazepam, clotiazepam, diazepam Etched cholesterol modified open tubular column Acetonitrile-10 mMTris-HCl, pH 7.3 (0-20 100-80) 700 mm x 50-75 pm i.d. 550 mm packed length 141... 

Benzodiazepines (nitrazepam, Cholesteryl bonded silica, nimetazepam, estazolam, 6.5 pm, 300 A brotizolam, clotiazepam, oxazolam, haloxazolam, cloxa-zolam, medazepam)... 

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