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Structure Clostridial neurotoxins

Chaddock, J.A. and Marks, P.M. 2006. Clostridial neurotoxins structure-function led design of new therapeutics. Cell. Mol. Life Sci. 63 540-551. [Pg.415]

Lebeda, F. J Umland, T. C Sax, M. Olson, M. A. (1998). Accuracy of secondary structure and solvent accessibility predictions for a clostridial neurotoxin C-fragment. J Protein Chem 17,311-8. [Pg.101]

Fig. 2. Structure and active site of clostridial neurotoxins. The upper panel shows the structure of CNTs, and the segments that show significant homology between the different serotypes are in black (Minton, 1995). The highest homology is shown by a short segment corresponding to the amino acid residues 216-244 in TeTx. This segment contains the zinc-binding motif of metallo-proteinases (zincins) and it is dissimilar to the consensus sequence of the metzincin metallo-proteinase family (Jiang and Bond, 1992)... Fig. 2. Structure and active site of clostridial neurotoxins. The upper panel shows the structure of CNTs, and the segments that show significant homology between the different serotypes are in black (Minton, 1995). The highest homology is shown by a short segment corresponding to the amino acid residues 216-244 in TeTx. This segment contains the zinc-binding motif of metallo-proteinases (zincins) and it is dissimilar to the consensus sequence of the metzincin metallo-proteinase family (Jiang and Bond, 1992)...
Kriegistein KG, Henschen AH, Weller U, Habermann E (1991) Limited proteolysis of tetanus toxin. In Eur. J. Biochem. 202 41 -51 Lebeda FJ, Olson MA (1994) Secondary structural predictions for the clostridial neurotoxins. Proteins 20 293-300... [Pg.189]

The family of structural genes for the clostridial neurotoxins is unrestricted in its location, being both chromosomal and extrachromosomal. The structural gene for tetanus toxin is on a plasmid, as is probably the structural gene for botulinum toxin serotype G.15 The structural genes for botulinum toxin serotypes C and D are found on bacteriophages.1017 The remainder are believed to be chromosomal in location, but this is not definitely proven. [Pg.647]

Lacy DB, Stevens RC. Sequence homology and structural analysis of the clostridial neurotoxins. / Mol Biol. 1999 291(5) 1091-1104. [Pg.334]

Li L, Singh BR Structure-function relationship of clostridial neurotoxins. J Toxicol-Toxin Reviews 1999, 8 95—112. [Pg.289]

See other pages where Structure Clostridial neurotoxins is mentioned: [Pg.135]    [Pg.136]    [Pg.140]    [Pg.169]    [Pg.170]    [Pg.170]    [Pg.170]    [Pg.190]    [Pg.404]    [Pg.418]    [Pg.392]    [Pg.362]   
See also in sourсe #XX -- [ Pg.135 ]



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Clostridial

Clostridial Structure

Clostridial neurotoxins

Neurotoxin

Neurotoxin structures

Structure of Clostridial Neurotoxins

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