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Clostridial neurotoxins light chain

Clostridial neurotoxins are bacterial protein toxins that consist of a heavy and a light chain connected by a disulfide bond and non-covalent interactions. They... [Pg.374]

The light chains of the clostridial neurotoxins are metalloproteases with exclusive specificity for neuronal SNAREs. TeNT, BoNTs B,D,F, and G cleave synapto-brevin, BoNTs A and E SNAP-25, and BoNT/Cl syntaxin, and to a lesser extent also SNAP-25. Cleavage of any of the SNAREs causes complete and irreversible block of synaptic transmission. [Pg.375]

See other pages where Clostridial neurotoxins light chain is mentioned: [Pg.136]    [Pg.170]    [Pg.194]    [Pg.220]    [Pg.233]    [Pg.392]    [Pg.362]   
See also in sourсe #XX -- [ Pg.136 ]



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Clostridial

Clostridial neurotoxins

Light chain

Neurotoxin

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