Closo-dodecaborates

Synthesis and characterization of gold-(l) and -(111) complexes with l-methyl-2-sulfanyl-l,2-dicarba-closo-dodecaborate. Journal of the Chemical Society, Dalton Transactions, (17), 2963-2967. 

Amongst the cioso-hydroborate anions the closo-dodecaborate B 2H 22 is the best known because many derivatives can be made by maintaining its icosahedral structure in substitution reactions. Thus the replacement of its hydrogen atoms... 

Cluster expansion of the Bn Hu cluster is possible on heating with triethylamine borane to give the dodecahydro-closo-dodecaborate (Eq. 62) [104] ... 

The dodecahalogeno-closo-dodecaborates Bi2Xi22 can be oxidatively transformed into polyboranes BnXn. However, the anions proved not to be suitable for developing a chemistry of their own, e.g., polymers based on Bi2 units or dendrimers. Therefore, functional hydro-closo-dodecaborates carrying reactive substituents are needed. 

FLUORINECOMPOUNDS,ORGANIC - FLUORINATED AROMATIC COMPOUNDS] (Vol 11) Decahydro-2,ll-bis(h5-cyclopentadienyl)-2, ll-dicobalt-l-carba-closo-dodecaborate(l-) ion [59422-34-3]... 

Peymann, T. Preusse, D. Gabel, D. Synthesis of S-glycosides of mercaptoundecahydro-closo-dodecaborate(2-). Larson, B. Crawford, J. Weinreich, R. Advances in neutron capture therapy Vol II. Amsterdam Elsevier 1997. pp. 35-37. 

Synthesis of 0-Bonded Derivatives of closo-Dodecaborate Anion. [B12]-[C2B10] Double Cage Boron Compounds - A New Approach to Synthesis of BNCT Agents... 

Figure 1. Radiochromatograms obtained using TLC a) 2lIAt distribution after oxidation and subsequent reduction of astatine in the absence of closo-dodecaborate and sodium iodide b) 2,1 At distribution after oxidation and subsequent reduction of astatine in the absence of closo-dodecaborate c) 2"At distribution after oxidation and subsequent reduction of astatine in the presence of closo-dodecaborate. d) Spontaneous labelling closo-dodecaborate in the absence of oxidising agent Sodium iodide carrier was added to the reaction mixture before analysis in samples b) c) and d). Merck silica gel 60F 254 TLC aluminium sheets were used and the eluent was acetone/0.1 M ammonia (9/1, v/v). The TLC strips (15x140 mm, elution path 120 mm) were measured on the Cyclone Storage Phosphor System and analysed on the OptiQuant Image Analysis Software.

Effect of Ionising Radiation on the Labelling of closo-Dodecaborate (2 ) Anion with 125I... 

Preliminary X-ray data have been reported for the Rb and Cs dodeca-hydro-closo-dodecaborates, M + B12H 2 the compounds are isomorphous and belong to the space group Fm3m.57 Data for the double salts with MCI have also been given. 

Derivatives of closo-dodecaborate anion and their use in medicine 02IZV1256. Polyhedral boron compounds as potential linkers for the attachment of radiohalogens to targeted proteins and peptides 02CCC913. 

Caution. Hydrogen peroxide must not come in contact with organic material or solvents, due to the possibility of fire or explosion. Extreme care must be taken to ensure the identity of the cesium dodecahydro-closo-dodecaborate reagent. The exposure of other polyhedral borane or carborane species to the reaction conditions described herein could result in spontaneous explosion. All reactions were conducted in well-ventilated hoods using additional polycarbonate blast shields. The product, Cs[B12(OH)12], must not be brought to dryness in the presence of peroxide solutions as the solid peroxide has been observed to be a shock-sensitive explosive. 

Br Se(p,n) Br 3.4 MeV (54%) 5.0 mm 16.2 hours Direct radiobromination with chloramine-T indirect conjugation using SPBrB, HPEM, brom-3-pyridine-carboxylate, closo-dodecaborate, i4o-undecaborate... 

Figure 6.7-4. Precursors used for residualizing radiobromination of monoclonal antibodies and peptides. Chemically reactive groups on the precursors are shaded, and site for radiobromination of the precursor is indicated in black and with an asterisk. SPBrB N-succinimidyl para-bromobenzoate Br-HPEM bromo-((4-hydroxy-phenyl) ethyl) maleimide Br-DABI bromo-(4 isothiocyanatobenzyl-ammonio)-bromo-decahydro-closo-dodecaborate.

Bruskin A, Sivaev I, Persson M, et al. (2004). Radiobromination of monoclonal antibody using potassium [ Br] (4 isothiocyanatobenzyl-ammonio)-bromo-decahydro-closo-dodecaborate (bromo-DABI). Nucl. Med. Biol. 31 205-211. 

Lee, J.-D., M. Ueno, Y. Miyajima, and H. Nakamura. 2007. Synthesis of boron cluster lipids Closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy. Org. Lett. 9 323-326. 

Sivaev, I. B., A. A. Semioshkin, B. Brellochs, S. Sjoberg, and V. I. Bregadze. 2000. Synthesis of oxonium derivatives of the dodecahydro-closo-dodecaborate anion [BuHu] ". Tetramethylene oxonium derivative of [BijHij] " as a convenient precursor for the synthesis of functional compounds for boron neutron capture therapy. Polyhedron 19 627-632. 

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