Clopidogrel Digoxin

Cardiovascular Acetyldigosin, ajmaline, amiodarone, aprindine, bepridil, bezaflbrate, captopril, dinepazide, clopidogrel, coumarins, diazoxide, digoxin, dipyridamole, disopyramide, doxazosin, enalapril, flurbiprofen, fur-oxemide, hydralazine, lisinopril methyldopa, metolazone, nifedipine, phenindione, procainamide, propanolol, propafenone, quinidine, ramapril, spironolactone, thiazide diuretics, ticlopidine, vesnarinone... 

Ginseng ASA, NSAIDs Antidiabetic agents Clopidogrel, ticlopidine CNS stimulants, caffeine Corticosteroids Digoxin MAO inhibitors Warfarin Additive antiplatelet effects Additive hypoglycemia Additive antiplatelet effects Additive CNS toxicity Additive CNS toxicity Falsely elevated levels Increased toxicity Increased risk of bleeding... 

In 12 healthy men steady-state clopidogrel 75 mg/day had no effect on the steady-state plasma concentrations of digoxin (256). 

Peelers PA, Crijns HJ, Tamminga WJ, Jonkman JH, Dickinson JP, Necciari J. Clopidogrel, a novel antiplatelet agent, and digoxin absence of pharmacodynamic and pharmacokinetic interaction. Semin Thromb Hemost 1999 25(Suppl 2) 51. ... 

No adverse interactions appear to occur with clopidogrel and alu-minium/magnesium hydroxide, atenolol, cimetidine, digoxin, food, insulin, nifedipine, oestrogens, phenobarbital, phenytoin or tolbutamide. 

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