Cloned mammalian adenylylcyclase

Nine cloned mammalian adenylylcyclases (ACs) can be activated by stimulatory a subunits (Gas) and several are modulated by inhibitory a subunits (Ckti) and/or Gp/y complexes. cAMP can activate the PKA, which in turn phosphorylates a wide range of substrates, such as the cAMP responsive element binding protein (CREB). When PICA translocates to the nucleus and phosphorylates CREB, the latter is stimulated to regulate gene transcription. There are three mammalian phospholipase C (PLC) isoforms families PLC-P, PLC-y and PLC-6. The first is activated by serpentine receptors, while the second is stimulated by RTKs. 

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See also in sourсe #XX -- [ , ]

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