Statistics clinical trials

Studies in Support of Special Populations Geriatrics General Considerations of Clinical Trials Statistical Principles for Clinical Trials... [Pg.188]

National Cancer Institute http //ctep.cancer.gov/ index.html Gateway to National Cancer Institute information and resources for cancer information, clinical trials, statistics, research programs, and research funding. [Pg.621]

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Senn SJ (1995) A personal view of some controversies in allocating treatment to patients in clinical trials. Statistics in Medicine 14 2661-2674. [See Comment in Statistics in Medicine 15(1) 113-116 (1996)]. [Pg.43]

Senn SJ (2004a) Added values controversies concerning randomization and additivity in clinical trials. Statistics in Medicine 23 3729-3753. [Pg.43]

Payers PM, Ashby D, Parmar MK (199 7) Tutorial in biostatistics Bayesian data monitoring in clinical trials. Statistics in Medicine 16 1413-1430. [Pg.54]

Lewis JA (1983) Clinical trials - statistical developments of practical benefit to the pharmaceutical industry. Journal of the Royal Statistical Society Series A - Statistics in Society 146 362-393. [Pg.65]

Schechtman KB, Gordon ME (1993) A comprehensive algorithm for determining whether a run-in strategy will be a cost-effective design modification in a randomized clinical trial. Statistics in Medicine 12 111-128. [Pg.88]

Senn SJ (1994) Testing for baseline balance in clinical trials. Statistics in Medicine 13 1715-1726. Senn SJ (1995a) Base logic baseline balance in randomized clinical trials. Qinical Research and... [Pg.88]

Lesaffre E, Senn S (2003) A note on non-parametric ANCOVA for covariate adjustment in randomized clinical trials. Statistics in Medicine 22 3583-3596. [Pg.109]

Senn SJ (1989) Covariate imbalance and random allocation in clinical trials [see comments]. Statistics in Medicine 8 467-475. [Comment in Statistics in Medicine 10(5) 797-799 (1991)]. Senn SJ (1994) Testing for baseline balance in clinical trials. Statistics in Medicine 13 1715-1726. Senn SJ (2000) Consensus and controversy in pharmaceutical statistics (with discussion). The Statistician 49 135-176. [Pg.145]

Longford NT (1999) Selection bias and treatment heterogeneity in clinical trials. Statistics in... [Pg.230]

Galbraith RF (1988) A note on graphical presentation of estimated odds ratios from several clinical trials. Statistics in Medicine 7 889-894. [Pg.268]

Simon R (1994) Some practical aspects of the interim monitoring of clinical trials. Statistics in Medicine 13 1401-1409. [Pg.314]

Everson-Stewart, S., Emerson, S.S. Bio-creep in non-inferiority clinical trials. Statistics in Medicine 29 2769-2780,2010. [Pg.51]

A recent study showed abnormal niacin sensitivity in schizophrenia patients as evidenced by attenuation of the flush response to niacin in schizophrenia. However, there is still an ongoing debate whether this response is due to altered pharmacological sensitivity to niacin or an inadequate cutaneous vasodilatory response to the stimulus (Messamore et al. 2003). Early studies even attempted to use niacin as an augmenting agent for the treatment of schizophrenia with mixed results (Ananth et al. 1973 Petrie et al. 1981). In a placebo-controlled comparative study by Ramsay et al. (1970), it was found that, while no significant differences were seen in total Brief Psychiatric Rating Scale (BPRS) scores prior to commencement of the clinical trial, statistically significant... [Pg.709]

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