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Clinical Reactivity of the Active Site

Mevinphos inactivates cholinesterase by phosphorylation of the active site of the enzyme to form the dimethylphosphoryl enzyme. Over the following 24—48 hours, there is a process, called aging, of conversion to the monomethylphosphoryl enzyme. Aging is of clinical interest in the treatment of poisoning because cholinesterase reactivators such as pralidoxime (2-PAM, Protopam) chloride are ineffective after aging has occurred. [Pg.497]

See other pages where Clinical Reactivity of the Active Site is mentioned: [Pg.651]    [Pg.476]    [Pg.483]    [Pg.517]    [Pg.446]    [Pg.272]    [Pg.374]    [Pg.443]    [Pg.287]    [Pg.319]    [Pg.446]    [Pg.651]    [Pg.476]    [Pg.483]    [Pg.517]    [Pg.446]    [Pg.272]    [Pg.374]    [Pg.443]    [Pg.287]    [Pg.319]    [Pg.446]    [Pg.430]    [Pg.553]    [Pg.75]    [Pg.345]    [Pg.877]    [Pg.195]    [Pg.105]    [Pg.146]    [Pg.199]    [Pg.199]    [Pg.289]    [Pg.288]    [Pg.967]    [Pg.262]    [Pg.36]    [Pg.348]    [Pg.247]    [Pg.484]    [Pg.485]    [Pg.166]    [Pg.235]    [Pg.189]    [Pg.995]    [Pg.537]    [Pg.60]    [Pg.276]    [Pg.67]    [Pg.59]    [Pg.63]    [Pg.1596]    [Pg.995]    [Pg.114]    [Pg.2045]    [Pg.655]   


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