Click 2 -pyrazinone

Decoration of the 2(1//)-Pyrazinone Scaffold Applying "Click Chemistry"... 

The availabiUty of functionalized 2(lH)-pyrazinone in combination with the use of microwave accelerated solid-phase chemistry constitutes a soUd foundation for generating large libraries of compoimds suitable for medicinal chemistry. The authors have also shown that the scaffold can be further functionalized using the principles of click-chemistry , thereby paving the way towards highly substituted 2-pyridone structures [45-47]. 

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