Click precursors

The strategic bond is disconnected by just clicking with the mouse on it. A suitable synthesis precursor is then generated automatically by WODCA by adding appropriate atoms or groups to the open valences. 

By clicking Save, you are telling the program to save this precursor and, in addition, to try to disconnect the target molecule in other ways (there may be other valid disconnections for the initial target molecule). 

By clicking Ignore, you are telling the program you do not want to save this precursor (possibly because you yourself have decided it is not the most suitable from a chemical point of view), but that you do want the programme to try and disconnect the molecule in some other ways. 

Note that a small synthesis tree with the numbers "1" and "2" has appeared. We will call each of the components of the tree a node. Click on node 2. In the active molecule window the ketone which the program has previously suggested appears. "Free.2 level 2" can now be read in the active molecule window, while the name of the disconnection appears in the lower part. By clicking on any node in the tree you will be able to see the precursor represented in this node. 

Aryl azides constitute central precursors for heterocyclic compound generation (e.g., click chemistry applications) [101]. Interestingly, a safe, convenient and microwave-compatible aryl azidonation process has been dis-... 

Various miidazo[l,5-a]imidazoles (35), itnidazo[l,5-a] pyridines (36), and iniidazo[5,l-a]isoquinolmes (37), important ligands or precursors to pharmaceuticals," can be constructed via copper-catalyzed heterocyclization of Schiff s bases. A stepwise cycloaddition between azides and terminal alkynes is also catalyzed by copper salts in what has now been termed click chemistry, producing 1,4-disubstituted triazoles (38) in excellent yields." ... 

Tsarevsky has found that hypervalent iodine compounds can be used for the direct azidation of polystyrene and consecutive click-type functionalization [49]. In particular, polystyrene can be directly azidated in 1,2-dichloroethane or chlorobenzene using a combination of trimethylsilyl azide and (diacetoxyiodo)benzene. 2D NMR HMBC spectra indicate that the azido groups are attached to the polymer backbone and also possibly to the aryl pendant groups. Approximately one in every 11 styrene units can be modified by using a ratio of PhI(OAc)2 to trimethylsilyl azide to styrene units of 1 2.1 1 at 0 °C for 4 h followed by heating to 50 °C for 2 h in chlorobenzene. The azidated polymers have been further used as backbone precursors in the synthesis of polymeric brushes with hydrophilic side chains via a copper-catalyzed click reaction with poly(ethylene oxide) monomethyl ether 4-pentynoate [49],... 

Scheme 1S.6 Click chemistry between a monocyclic prepolymer having an alkyne group and linear telechelic precursor with azide end groups, resulting in the selective formation of a fcndged-dicyclic manacle-shaped polymer.

Narrow-polydispersity cydic poly(caprolactone) was synthesized by cyclization of linear precursors prepared via ring-opening polymerization bom an azido-functionalized initiator, followed by end-group modification to attach a terminal alkyne. Click coupling afforded the cyclic polymer in high... 

The synthesis of a 7-arm star PCL was reported by clicking an acetylene-funaionalized PCL precursor 20, prepared by ROP of fi-caprolaaone e-CL at 110 °C, using 5-hexyn-l-ol as initiator, with heptakis-azido-p-cyclodexttin 21 (Scheme 42). The dick reaction was performed under microwave irradiation at 100 °C. To induce complete functionalization of the P-cyclodexttin, nine equivalents of the acetylene-functionalized PeCL were used in the coupling reaction. After the reaction, the excess PeCL was removed from the star by preparative SEC. 

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