Click chemistry poly -based

As a basis for hydrogels, hyperbranched polymers [41] can also be used. These polymers can be connected by click chemistry in miniemulsion droplets in order to obtain hyperbranched polyglycerol (HPG)-based particles. Such materials are of great interest for drug release because they are nontoxic [42, 43] and show similar behavior to poly(ethylene glycol)s. 

The ability of thiol-ene click chemistry to retain high efficiency under the most benign reaction conditions was exempHfied by Ritter and Bardts, in the preparation of hydrogels based on methacryhc acid [224]. In this study, poly(methacrylic acid) polymers were modified with cysteamine and aUyl amine to afford complementary thiol-ene reactive polymer chains. Solutions of the polymer pairs in water were mixed in the presence of a radical initiator, and the formation of a highly elastic gel was observed within only 2 h at room temperature. The authors noted that this approach might have broad application for a rapid and straightforward access to hydrogel materials for which the properties could easily be tailored by the choice of the amine modifiers. 

Post-modification route for preparation of smart hybrid GNPs with poly (4-vinylpyridine) (P4VP) based on RAFT and click chemistry... 

Describe a synthetic strategy for preparation of cyclic poly(N-isopropylacrylamide) of polymerization degree approximately 100, based on RAFT polymerization and click chemistry. 

Urien, M., Erothu, H., Cloutet, E. et al. (2008) Poly(3-hexylthiophene) based block copolymers prepared by Click chemistry. Macromolecules, 41,7033-7040. 

Finally, azide-aUcyne click chemistry has been used to attach Choi, modified with a propargyl group, to poly(3-azidomethyl-3-methyloxetane), prepared by a cationic ROP [177]. High conversion of the azide groups is achieved with excess of Chol-propargyl. As mentioned, there are a number of methods to attach Choi (and/or menthol), with OH functionalities, to synthetic polymers so as to combine the properties of the two. The same synthetic methods should be applicable to other (functional) terpenes, which would certainly expand the family of terpene-based bioconjugate polymers. 

Ossipov DA, Hilbom J (2006) Poly(vinyl alcohol)-based hydrogels formed by click chemistry . Macromolecules 39 1709-1718... 

Covalent LbL assembly based on click chemistry, especially CuAAC, has also been exploited comprehensively [83-95]. Caruso and coworkers built up covalently crosslinked multilayers on silicon, quartz, or gold-coated substrates by alkyne- and azide-functionalized poly(acrylic acid) (PAA) copolymers [83]. The results showed... 

---