Click chemistry photoinitiated

Figure 8.3 General scheme for the divergent synthesis of dendrimers using a photoinitiated thiol-ene click chemistry, as developed by Hawker et al. (Reprinted with permission from K.L. Killops, L.M. Campos and C.J. Hawker, Robust, efficient, and orthogonal synthesis of dendrimers via thiol-ene click chemistry, Journal of the American Chemical Society, 130, 15, 5062-5064, 2008. 2010 American Chemical Society.)...

In a further, and more comprehensive investigation into radical-based thiol-ene chemistry. Hawker and colleagues prepared a series of polymers with either single or multiple alkene functionality and clicked on a variety of commercially available mercaptans under both photoinitiation (with trace amounts of DMPA) and thermal initiation (in the presence of radical initiator 2,2 -azobis(2-methylpropionitrile)) (Campos et al, 2008). In aU cases studied, the photoinitiated thiol-ene reactions (all performed at ambient temperature) could be made to proceed to completion in times ranging from 30 min to 2h. 

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