Click chemistry expansion

Figure 45 Click chemistry has been used to establish LbL growth of PAA on silica microparticle templates. After removal of the silica core particles, the microcapsules retain alkynyl and azido reactive groups and also exhibit pH-responsive expansion and contraction because of the acrylic acid functionalities. Reproduced with permission from Such, G. K. Tjipto, E. Postma, A. etal. Nano Lett. 2007, 7(6), 1706-1710. ...

Someya T, Ando A, Kimoto M, Hirao I (2015) Site-specific labeling of RNA by combining genetic alphabet expansion transcription and copper-fiee click chemistry. Nucleic Acids Res. doi 10.1093/ nar/gkv638... 

The polymeric/ soft materials chapter represents the largest expansion for the 2nd edition. This chapter describes all polymeric classes including dendritic polymers, as well as important additives such as plasticizers and flame-retardants, and emerging applications such as molecular magnets and self-repairing polymers. This edition now features click chemistry polymerization, silicones, conductive polymers and biomaterials apphcations such as biodegradable polymers, biomedical devices, dmg delivery, and contact lenses. 

Figure 9.7 Design of tandem hydrocarbon-stapled ( stitched ) peptides and expansion of click-stapling chemistry, including bis-triazolo-aiyl-stapling, to various intracellular targets.

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