Cleome icosandra

Nair AGR (1979) Cleosandrin, a Novel 7-Phenoxycoumarin from the Seeds of Cleome icosandra. Indian J Chem 17B 438... 

The herb Cleome viscosa (syn. cleome icosandra)y which is widely distributed in India, has long been recognized by the native population to serve as a rubefaciant, vesicant, and anthelmintic agent. As a consequence of these reputed properties, three research groups undertook almost simultaneously in the late 1970 s to determine the principal active constituent of this sticky, odoriferous plant [82,83]. On the basis of the NMR, X-ray, and CD data, the substance was determined to be the macrocyclic diterpene lactone 160 and named cleomeolide. The structural features of this macrolide are unusual in several respects (a) the double bond positioned a,p to the lactone carbonyl resides at a bridgehead site, a... 

Marine organisms have again continued to provide some-very unusual diterpenoids. The sea-pen, Stylatula sp., was the source of the compounds (72) and (73). X-Ray analysis has shown that cleomeolide, from Cleome icosandra, has the structure (74). A further diterpenoid related to eunicellin, ophirin (75), has been obtained from a Muricella sp. A full paper on the ether dictyoxide (76) has appeared. ... 

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