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Clavulinic acid

T ranspeptidation Non-growing spheroplasts Mecillinam, clavulinic acid, thienamycin... [Pg.214]

The stability of the acylated enzyme may be rationalized to be due to vinylogous structure of the urethane-type product formed. Analogous mechanisms have been proposed for sulbactam and clavulinic acid. Clavulinic acid can also form an acylated equilibrium between an enamine and imino intermediate. The nonvinylogous, and presumably, some-... [Pg.234]

Clavulinic acid iminoacyl intermediate eneamine intermediate... [Pg.235]

Early penicillin (Pen G) was acid labile and could not be administered orally. It was ineffective against many Gram-negative bacteria and was destroyed by P-lactamases. Each of these limitations has been overcome in newer penicillins due to alterations of the chemical structure or the development of adjunct agents such as probenicid and clavulinic acid. These... [Pg.104]

Figure 7.11. Penicillinases and penicillinase-resistant penicillins. Top Penicillins destroy bacteria after binding to penicillin binding proteins (PBPs). Middle Penicillinases are enzymes produced by bacteria that destroy penicillins by cleaving the beta-lactam ring of the drug. Penicillins are "lured" into the active site because they are chemically similar to penicillin binding proteins. Bottom Clavulinic acid is a "decoy" drug that enhances the activity of penicillins. Clavulinic acid binds to the active sites of penicillinases rendering the enzyme inactive. Figure 7.11. Penicillinases and penicillinase-resistant penicillins. Top Penicillins destroy bacteria after binding to penicillin binding proteins (PBPs). Middle Penicillinases are enzymes produced by bacteria that destroy penicillins by cleaving the beta-lactam ring of the drug. Penicillins are "lured" into the active site because they are chemically similar to penicillin binding proteins. Bottom Clavulinic acid is a "decoy" drug that enhances the activity of penicillins. Clavulinic acid binds to the active sites of penicillinases rendering the enzyme inactive.
Clavulinic acid P-Lactamase In combination with penicillins Bacterial... [Pg.166]

Clavulinic acid has been converted into the pen-2-em system via a betaine intermediate as shown in Scheme 133. A related paper describes the conversion of a chiral penicillanic acid into a pen-2-em-3-carboxylic acid. The penem ring system has also been obtained by a novel oxidative addition process mediated by copper(i). The simplest example is illustrated in Scheme 134. [Pg.331]

P-lactam with 3-lactamase inhibitor Ampicillin/sulbactam Ticarcillin/clavulinic acid Piperacillin/tazobactam... [Pg.105]

See other pages where Clavulinic acid is mentioned: [Pg.119]    [Pg.108]    [Pg.255]    [Pg.50]    [Pg.215]    [Pg.235]    [Pg.105]    [Pg.119]    [Pg.108]    [Pg.255]    [Pg.50]    [Pg.215]    [Pg.235]    [Pg.105]    [Pg.104]   
See also in sourсe #XX -- [ Pg.5 , Pg.609 , Pg.718 , Pg.869 , Pg.870 ]

See also in sourсe #XX -- [ Pg.730 , Pg.744 ]



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