Cisplatin Valproate

Cisplatin Carbamazepine Phenytoin Valproate Reduced effect of phenytoin interaction poorly documented Unknown... 

Increased effects (P450 3A4 inhibitors) cimetidine, danazol, diltiazem, erythromycin, troleandomycin, clarithromycin, fluoxetine, isoniazid, niacinamide, nicotinamide, propoxyphene, ketoconazole, itraconazole, verapamil,and valproate Decreased effects (P450 3A4 inducers) cisplatin, doxorubicin, felbamate, rifampin, phenobarbital, phenytoin, primidone, theophylline... 

Phenytoin Carbamazepine Sodium valproate Doxorubicin Cisplatin Cyclophosphamide Altretamine Papillary adenocarcinoma of the ovaries Seizures occurred 2 to 3 days after starting chemotherapy. All drug levels dropped to one-third or iower. Doses increased to compensate, which led to phenytoin toxicity when the chemotherapy finished. 5... 

Sodium valproate Phenytoin Cisplatin Etoposide Bleomycin Testicular cancer Serum valproate levels reduced by 50% after the first cycle and generalised tonic-clonic seizures occurred. There was no effect on phenytoin levels. 13... 

One report found valproate increased haematological toxicity in patients taking valproate with fotemustine and cisplatin. ... 

Bouig V, Lebrun C, Chichmanian RM, Thomas P, Frenay M. Nitroso-urea-cisplatin-based chemodierapy associated with valproate increase of haematologic toxicity. z4nw O co/(2001)... 

Carbamazepine levels are increased by CYP3A4 inhibitors (cimetidine, macrolides, diltiazem, fluoxetine, ketoconazole, verapamil, valproate) levels are decreased by CYP3A4 inducers (cisplatin, doxorubicin, felbamate, phenobarbital, phenytoin, primidone, rifampin, theophylline). Carbamazepine may increase levels of clomipramine, phenytoin, and primidone and lithium toxicity may decrease levels of phenytoin, warfarin, oral contraceptives, doxycycline, theophylline, haloperidol, alprazolam, clozapine, ethosuximide, and valproate may interfere with other anticonvulsants. 

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