Cisplatin hypocalcemia with

Ocular toxicity of cisplatin has been reported in a 47-year-old woman who experienced rapid uncontrollable eye movements associated with hypomagnesemia and hypocalcemia in the presence of renal tubular damage (123). 

Other electroljde disturbances induced by cisplatin include hypocalcemia, hjq)ophosphatemia, hyponatremia, and hypokalemia (164,165). However, these changes are rarely associated with symptoms (166,167). 

Gonzalez C, Villasanta U. Life-threatening hypocalcemia and hypomagnesemia associated with cisplatin chemotherapy. Obstet Gynecol 1982 59(6) 732. ... 

Acute renal failure due to cisplatin therapy is usually partially reversible with time and supportive care, including dialysis. Serummag-nesium concentrations should be monitored frequently and hypomagnesemia corrected (see Chap. 50). Hypocalcemia and hypokalemia may be difficult to reverse until hypomagnesemia is corrected. Progressive chronic kidney disease due to cumulative toxicity may not be reversible and in some cases may require chronic dialysis support. 

Hypomagnesemia has been associated with more than 50 drugs, especially those that are nephrotoxic, including cisplatin, aminoglycoside antibiotics, cyclosporine, and amphotericin B. Secondary hypocalcemia and hypokalemia may result with myasthenia and tetany (Swaminathan 2003). 

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