Cisplatin also discovery

Cisplatin, (ds-[PtCl2(NH3)2], also known as cis-DDP) ((1), Figure 2) is perhaps the best known example of a small molecule metal-containing drug. The clinically used platinum complexes are shown in Figure 2. The history of the discovery and development of cisplatin remains a remarkable scientific story.33 Its use and effectiveness in cancer chemotherapy since the entry into the clinic in the late 1970s has been thoroughly documented.34-36 Cisplatin is cited for treatment of... 

The serendipitous discovery of the antitumor activity of cisplatin opened a huge field of research, leading to significant advances and successes in cancer chemotherapy [181]. Cisplatin and its analogues are reactive complexes that exhibit pharmacokinetic, pharmacodynamic, and toxicological behaviors so closely interdependent as to be all but impossible to untangle. Our focus here is and remains metabolism, but some considerations regarding activity and toxicity are also addressed. 

After thirty years of research, cisplatin has led to the discovery of several new generation anticancer drugs discussed in this book. Cisplatin has also become an outstanding tool to study all aspects of DNA properties, from reaction with small cationic species to interaction with proteins which induce biological signals triggering apoptosis. 

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