Cisatracurium Succinylcholine

NMBAs are further differentiated by their duration of action during anesthesia. Succinylcholine and mivacurium are common ultra-short-acting competitive NMBAs (5-10 min). An intermediate duration of action (30-45 min) is maintained with the use of atracurium, cisatracurium, rocuronium and vecuronium. A long-lasting duration of action (90-100 min) is observed with d-tubocurarine, doxacurium, metocurine, pancuronium and pipecuronium. 

Less commonly, NMBAs are classified based on their chemical nature to include namral alkaloids and their congeners (e.g. d-tubocurarine), aminosteroids (e.g. cisatracurium, vecuronium) and benzylisoquinolines (e.g. succinylcholine). This classification scheme also relates to mechanism of actions and associated effects. 

C. Known hypersensitivity or anaphylactic reaction (non-dose-related) to agent or presenrative (eg, benzyl alcohol). Succinylcholine is most commonly implicated, but anaphylaxis has been reported with rocuronium, atracurium, mi-vacurium, and cisatracurium. 

The effects of cisatracurium, mivacurium, pancuronium, rocuro-nium, tubocurarine, vecuronium, and probably other competitive neuromuscular blockers can be increased and prolonged by magnesium sulfate given parenterally. There is some evidence that magnesium may interact similarly with suxamethonium (succinylcholine), but also evidence from well-controlled trials that it does not. 

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See also in sourсe #XX -- [ ]

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