Cis-Dichlorobis

The only prominent antitumor tetravalent platinum complex so far is iproplatin (102). In vitro it has been shown to cause interstrand DNA-breaking and cross linking. Free radical scavengers inhibit these effects. The complex is less neurotoxic and less nephrotoxic than cisplatin. Its synthesis begins with hydrogen peroxide oxidation of cis-dichlorobis(isopropvlamine) platinum (100) to the dimethylacetamide complex 101. The latter is heated in vacuum to liberate iproplatin [25]. 

C. (+ )589-A-cis-DICHLOROBIS(l, 2-ETHANEDIAMINE)-CHRO MIUM(III) CHLORIDE MONOHYDRATE... 

E. coli Gene mutations No data + Sugden et al. 1990 cis-Dichlorobis (2,2 -bipyridyl) chromium(lll)... 

Neuse EW, Meirim MG, Blom NF (1988) Metallocene-containing platinum complexes as potential antitumor agents. 1. Dichloro(l, 6-differrocenyl-2, 5-diazahexane)platinum(II) and cis-dichlorobis(l-ferrocenylethylamine)platinum(II). Organometallics 7 2562-2565... 

One of Tobe s complexes, cis-dichlorobis(cyclohexylamine)plati-num(II) was tested by T. A. Connors against the ADJ/PC6 myeloma tumor in mice. It cured the tumors completely at a dose 1/500 of the LD50. Such specificity, especially in the absence of any evidence of selective tumor up-... 

Tris(diamine) complexes of chromium(III) have been important from several viewpoints. First, the tris(ethylenediamine) complex is valuable as a synthetic intermediate,1 the action of heat on the chloride salt giving the cis-dichlorobis(ethylenediamine) complex and on the thiocyanate salt giving the irans-bis(iso-thiocyanato) complex. Second, the cations are resolvable, and studies2 of their optical activity have been fruitful in establishing relations between signs of Cotton effects and absolute stereochemistries. A large number of other studies, including kinetic and equilibrium measurements, have shown these complexes to be readily hydrolyzed to bis(ethylenediamine) complexes.3... 

Also, analogous selenourea complexes of tellurium have been prepared (e.g., 126, 136, 138). cis-Dichlorobis(thiourea)-selenium(II), Se(tu)2Cl2, and the homologous dibromo complex were prepared as the first compounds of this series with selenium as central atom (50). 

Chromium(ll), cis-dichlorobis( 1,2-ethanedi-amine)-, chloride, resolution of, 26 24, 27... 

Quantitative photoisomerizations of cis-dichlorobis(pyridine)platinum(II) in CHClj provide evidence for the simultaneous operations of several isomerization mechanisms ... 

The borohydride reduction of neutral or strongly alkaline suspensions of cis-dichlorobis(bipyridyl)rhodium(III) salts gives para-... 

Two mmoles of the corresponding cis-[dichlorobis(nucleoside)palladium(II)] (1.4274 g for the inosine and 1.4882 g for the guanosine complex) are placed in a 100-mL beaker containing a magnetic stirring bar. Upon addition of about 50 mL of distilled water (with stirring) the initial complex dissolves, and, almost instantaneously (after 10-15 min for inosine), a new, yellow precipitate is formed. The pH of this water suspension becomes acidic, due to the liberation of HC1. The stirring is continued for about two hours to attain completion of the reaction, while the pH is kept between 6.0 and 6.5 by the dropwise addition of a solution of 0.1 N KOH. The final pH value of the suspension should be 6.0-6.5. 

Fig. 12.21 (a) Optical isomers of cis-dichlorobis[Pg.493]

Into a SO-mL Schlenk flask is weighed 0.2S g of the recrystallized cis-dichlorobis(trimethylphosphine)platinum(II). Under a nitrogen atmosphere, the solid is suspended in 10 mL of methanol (refluxed under nitrogen and distilled from magnesium). To the suspension is added 3 mL of diethylamine (distilled and stored under nitrogen), and the suspension is stirred until the solid dissolves. Then 1 equiv (0.022 g) of sodium tetrahydroborate(l —) is added and stirring continued for about S min until gas evolution ceases. The... 

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