Circular dichroism chiral molecules

Freedman TB, Cao X, Dukor RK, Nafie LA (2003) Absolute configuration determination of chiral molecules in the solution state using vibrational circular dichroism. Chirality 15 743-758... 

Although the usual absorption and scattering spectroscopies caimot distinguish enantiomers, certain techniques are sensitive to optical activity in chiral molecules. These include optical rotatory dispersion (ORD), the rotation by the sample of the plane of linearly polari2ed light, used in simple polarimeters and circular dichroism (CD), the differential absorption of circularly polari2ed light. 

C. Photoelectron Circular Dichroism Photoelectron Dynamics in Chiral Molecules... 

Ever since Pasteur s work with enantiomers of sodium ammonium tartrate, the interaction of polarized light has provided a powerful, physical probe of molecular chirality [18]. What we may consider to be conventional circular dichroism (CD) arises from the different absorption of left- and right-circularly polarized light by target molecules of a specific handedness [19, 20]. However, absorption measurements made with randomly oriented samples provide a dichroism difference signal that is typically rather small. The chirally induced asymmetry or dichroism can be expressed as a Kuhn g-factor [21] defined as ... 

C. J. Harding, Photoelectron Circular Dichroism in Gas Phase Chiral Molecules, Ph.D. thesis. University of Nottingham, UK, 2005. 

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