Ciprofloxacin arrhythmia with

The incidence of serious cardiac arrhythmia with the use of fluoroquinolones was investigated in a retrospective, nested case-controlled study. Fluoroquinolones were associated witir an increased risk of serious cardiac arrhythmia (RR 1.76) with gatifloxacin giving the highest risk (RR7.38), followed by moxifloxacin (RR 3.30) and ciprofloxacin (RR 2.15) [20 ]. Hypersensitivity reactions to fluoroquinolones are more likely in subjects who have had a previous reaction to beta-lactam antibiotics (OR 4.57) [21 ]. 

DULOXETINE ANTIBIOTICS -CIPROFLOXACIN t duloxetine levels with risk of side-effects, e.g. arrhythmias Inhibition of metabolism of duloxetine Avoid co-administration... 

Established interactions. Based on the results of two studies, on a scale of 100 to 0, the relative potencies of these quinolones as inhibitors of caffeine elimination have been determined as follows enoxacin 100, pipemidic acid 29, ciprofloxacin 11, norfloxacin 9 and ofloxacin 0. From further studies, clinafloxacin appears to be similar to enoxacin (profound effect), pefloxacin to norfloxacin (to which it is metabolised modest effect), and fleroxacin, lomefloxacin, rufloxacin, and trovafloxacin appear to behave like ofloxacin (no effect). Patients taking enoxacin might be expected to experience an increase in the effects of caffeine (such as headache, jitteriness, restlessness, insomnia) if, for example, they continue to drink their usual amounts of caffeine-containing drinks (tea, coffee, cola drinks, etc.). They should be warned to cut out or reduce their intake of caffeine if this occurs. The authors of one report suggest that patients with hepatic disorders, cardiac arrhythmias or latent epilepsy should avoid caffeine if they take enoxacin for one week or more. The effects of pipemidic acid arc less, and those of ciprofloxacin, norfloxacin and pefloxacin arc probably of little or no clinical importance. Fleroxacin, lomefloxacin, ofloxacin, rufloxacin, and trovafloxacin do not interact. 

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