Ciprofloxacin acute generalized

Skin Acute generalized exanthematous pustulosis (AGEP) has been attributed to cefotaxime in a 30-year-old woman who received cefotaxime, fosfomydn, and ciprofloxacin for sinusitis for 12 days the symptoms resolved within 11 days after cefotaxime withdrawal. Patch tests were positive to cefotaxime after 48 hours and negative to ciprofloxacin and fosfomydn [10 ]. 

It is reasonable to conclude that in general, quinolones are safe drugs from the renal point of view. It is often difficult, however, to ascertain the exact causative role of these agents in the appearance of nephrotoxicity. Judging by the recent accumulated experience with ciprofloxacin, physicians using quinolones should be alert for the development of acute interstitial nephritis leading to renal failure. This concern should be extended to the other newer fluoroquinolones despite the paucity of reports dealing with nephrotoxicity. 

---