Ciprofloxacin Charcoal, activated

Small doses of activated charcoal appear to have little effect on the absorption of ciprofloxacin and oral contraceptives (administration separated), and only modestly reduces nizatidine absorption. Case reports describe the lack of efficacy of mitobronitol and reduced serum phenobarbital levels in the presence of small doses of activated charcoal. 

Activated charcoal is also included in various remedies used for gastrointestinal disorders such as flatulence or diarrhoea. Doses in these instances are very much lower (1 to 2 g daily) than those used in the treatment of poisoning, and there seems to be little reported about the effects of these doses on the absorption of other drugs. In one single-dose study in healthy subjects, nizatidine absorption was reduced by about 30% when it was taken one hour before activated charcoal 2 g. In another single-dose study in 6 subjects, taking activated charcoal 1 g soon after ciprofloxacin 500 mg, had little effect on the pharmacokinetics of ciprofloxacin 500 mg (AUC reduced by 10%). ... 

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