Cinnoline-3-propionic acids

Dioxopyridoquinoline-2,8-dicarboxylic acids, cinnoline-3-propionic acids and 4-oxoquinoline-3-tetrazoles The pyridoquinoline dicarboxylic acid series has been explored by Upjohn and ICI (53- J). An angular pyridoquinoline, ICI 74,917 (bufrolin), is active in man by the aerosol route (fifi). The linear compound A (LXXXIX) is reported by Upjohn workers to be orally active in the PCA procedure (59). 

ICI workers have also reported activity for a series of cinnoline-3-propionic acid derivatives (XC), with oral ED50 values as low as 4 mg/kg for the 6-ethyl compound (M). 

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