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Cinchona succiruba

Quinine (44), cinchonicinol (45), and cinchonaminone (46), isolated from Cincho-nae cortex Cinchona succiruba, Rubiaceae), inhibited MAO from bovine plasma in assays using benzylamine as the substrate [68], The IC50 values calculated for MAO inhibition were 16 pM (44), 12 pM (45), and 32 pM (46), and kinetic experiments indicated that quinine (44) acted as a competitive MAO inhibitor. [Pg.143]

The genus Cinchona includes about 40 tree species, of which about 12 are of commercial importance. Alkaloids in the bark of Cinchona officinalis occur in an amount of 5-8%, of which 2-7.5% is quinine (10-22). The total alkaloid content of C. succiruba (syn. C. pubescens) bark is 6-16% (quinine content is 4-14%), 5-14% (3-13% represents quinine) is in the bark of C. ledgeriana and 3-7%, of which 0-4% is quinine, occurs in C. calisaya bark. [Pg.771]

See other pages where Cinchona succiruba is mentioned: [Pg.59]    [Pg.779]    [Pg.780]    [Pg.121]    [Pg.59]    [Pg.779]    [Pg.780]    [Pg.121]   
See also in sourсe #XX -- [ Pg.209 , Pg.211 ]

See also in sourсe #XX -- [ Pg.26 , Pg.779 , Pg.780 , Pg.820 ]

See also in sourсe #XX -- [ Pg.780 , Pg.820 ]

See also in sourсe #XX -- [ Pg.29 ]

See also in sourсe #XX -- [ Pg.139 ]



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