Cimetropium bromide

Kajbaf M, Jahanshahi M, Pattichis K, Gorrod JW, Naylor S (1992) Rapid and efficient purification of cimetropium bromide and mifentidine drug metabolite mixtures derived from microsomal incubates for analysis by mass spectrometry. J Chromatogr 575 75-85... 

C4H7Br 7051-34-5) see Betaxolol Cimetropium bromide Fluloprazepatn Naltrexone Prazcpam A,-cyclnpropylin ethyl-6,14-e mfo-ethano-7o - (lS)-l-hydroxy-1,2,2-trimcthylpropyl tctrahydronorthebaine (CmH NOj 16524-65 5) see Buprenorphine (2-cyclopropyl-2-oxoethyl)triphcnylphosphonium bromide... 

Cimetropium bromide is an anticholinergic drug that belongs to a series of scopolamine quaternary salts with strong antimuscarinic effects (1). 

Scarpignato C, Bianchi Porro G. Cimetropium bromide, a new antispasmodic compound pharmacology and therapeutic perspectives. Int J Clin Pharmacol Res 1985 5(6) 467-77. 

A meta-analysis of 23 randomized chnical trials assessing the efficacy and tolerance of smooth muscle relaxants in irritable bowel syndrome has shown that these drugs are superior to placebo (2). Six drugs were analysed cimetropium bromide (five trials), hyoscine butyl bromide (three trials), mebeverine (five trials), otilium bromide (four trials), pinaverium bromide (two trials), and trimebutine (four trials). There was no overall significant difference in the frequency of adverse effects compared with placebo. 

S Naylor, M Kajbaf, JH Lamb, M Jahanshahi, JW Gorrod. Rapid identification of cimetropium bromide metabolites using constant neutral loss tandem mass spectrometry. Biol Mass Spectrom 21 165, 1992. 

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