Doxazosin Cimetidine

Also analj ed acebutolol, alprenolol, antazoline, betaxolol, bisoprolol, bopindolol, bupran-olol, carteolol, celiprolol, chloropyramine, chlorpheniramine, cicloprolol, cimetidine, cin-narizine, cirazoline, clonidine, dilevalol, dimethindene, diphenhydramine, doxazosin, es-molol, famotidine, isothipendyl, ketotifen, metiamide, metoprolol, moxonidine, nadolol, naphazoline, nifenalol, nizatidine, oxprenolol, pheniramine, phentolamine, pindolol, pi-zotyline (pizotifen), practolol, prazosin, promethazine, propranolol, pyrilamine (mepyra-mine), ranitidine, roxatidine, sotalol, tiamenidine, timolol, tramazoline, tripelennamine, triprolidine, tymazoline, UK-14,304... 

The manufacturers of doxazosin note that in a placebo-controlled study in healthy subjects cimetidine 400 mg twice daily increased the AUC of a single 1-mg dose of doxazosin given on day 4 by 10%. This seems unlikely to be of clinical significance, especially as this is within the expected intersubject variation of the doxazosin AUC. ... 

No important interaction occurs between cimetidine and either alfuzosin or doxazosin. Tamsulosin does not appear to have a clinically significant interaction with cimetidine, but caution is recommended with high tamsulosin doses. 

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