Cilostazol SSRIs

CILOSTAZOL ANTIDEPRESSANTS-SSRIs Fluoxetine, fluvoxamine and sertraline t cilostazol levels Fluoxetine, fluvoxamine and sertraline inhibit CYP3A4-mediated metabolism of cilostazol Avoid co-administration... 

Cilostazol Inhibitors of cytochrome P450 isoenzyme CYP3A4 are predicted to increase the serum levels of cilostazol or its active metabolite (all SSRIs potentially affected). 

In view of these effects the US manufacturers suggest halving the dose of cilostazol in the presence ofCYP3A4 inhibitors such as erythromycin, diltiazem, itraconazole, and ketoconazole. However, the UK manufacturers contraindicate CYP3A4 inhibitors, and they specifically name erythromycin, diltiazem, ketoconazole, cimetidine, and the protease inhibitors. Just why these recommendations differ is not clear. The US manufacturers suggest that other CYP3A4 inhibitors, such as azole anti-fungals (fluconazole, miconazole), SSRIs (fluoxetine, fluvoxamine, sertraline) and nefazodone, may also interact. ... 

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See also in sourсe #XX -- [ ]

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