Cilostazol adverse effects

CILOSTAZOL ANAGRELIDE Risk of adverse effects Additive effect anagrelide has phosphodiesterase inhibitory activity Avoid co-administration... 

The efficacy and safety data of cilostazol in placebo-controlled clinical trials have been repeatedly subjected to meta-analysis, with the same conclusion (1,2). Cilostazol is well tolerated headache, bowel complaints, and palpitation are the most common but mild adverse effects. 

In another placebo-controUed trial, there were gastrointestinal complaints in 44% of the cilostazol-treated patients and in 15% of the placebo group. The most commonly reported adverse effects included diarrhea, loose stools, flatulence, and nausea they were usually mild and transient but persisted in some patients. Headache occurred in 20% of cilostazol-treated patients but also in 15% of those given placebo (7). 

Food increases the bioavailability of cilostazol, which may increase adverse effects. 

A randomised, single-dose, crossover study in 15 healthy subjects found that giving cilostazol 1(X) mg within 10 minutes of a high fat meal caused an increase in the rate and extent of cilostazol absorption. The maximum plasma concentration of cilostazol was increased by about 95%, the AUC was increased by 25%, and the half-life decreased from 15.1 to 5.4 hours, when compared with the fasted state. The manufacturer recommends that cilostazol should be taken 30 minutes before or 2 hours after food, because the increase in maximum plasma concentrations of cilostazol when taken with food may be associated with an increased incidence of adverse effects. ... 

Umazume T, Funabashi N, Inoue T, Nishi T, Shimizu T, Jo K, et al. Adverse effects of cilostazol on left ventricular function in a patient with a sigmoid shaped interventricular septum. Int J Cardiol May 25,2013 165(3) 551-5. 

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