Cilium-centrosome complex

Renal hypoplasia, dysplasia and cystic renal diseases comprise many entities that sometimes are diagnostically challenging. However, there is increasing evidence that on a cellular and genetic level many or most of them have a common pathogenetic pathway centered at the cilium-centrosome complex. With the help of the clinical information, the onset and patient age, the family history and the genetic results, diagnosis can be made in the majority of cases without invasive procedures such as renal biopsy. The location and size, distribution and onset of cysts and parenchymal abnormalities can help to... 

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