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Melphalan Ciclosporin

CICLOSPORIN MELPHALAN Risk of renal toxicity Additive effed Monitor U Es closely... [Pg.358]

Melphalan appears to increase the nephrotoxic effects of ciclosporin. [Pg.1038]

A comparative study found that 13 out of 17 patients receiving bone marrow transplants and given ciclosporin 12.5 mg/kg daily with high-dose melphalan (single injection of 140 to 250 mg/m ) developed renal failure, compared with no cases of renal failure in 7 other patients given melphalan but no ciclosporin. In another study, one out of 4 patients given both drugs developed nephrotoxicity. The reasons are not understood. Renal function should be monitored closely on concurrent use. [Pg.1038]

See other pages where Melphalan Ciclosporin is mentioned: [Pg.1038]    [Pg.1038]    [Pg.17]    [Pg.17]   
See also in sourсe #XX -- [ Pg.1038 ]



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