Ciclosporin Ezetimibe

CICLOSPORIN EZETIMIBE T levels of both drugs when ezetimibe is co administered with cidosporin Uncertain Watch for signs of cidosporin toxicity... 

Unknown Ciclosporin (raised plasma ezetimibe, ciclosporin) Monitor ciclosporin level... 

The levels of ezetimibe and possibly ciclosporin may be elevated by their concurrent use, and so the combination should be used with caution. 

A randomised, crossover study in 12 healthy subjects found that ezetimibe 20 mg daily for 8 days increased the AUC of a single 100-mg dose of ciclosporin by 15%. The authors noted that it would be difficult to determine the outcome of long-term concurrent use, but the modest effect seen suggested that caution was necessary if the combination was given. However, an efficacy study noted that in 16 renal transplant patients the addition of ezetimibe 10 mg daily had no effect on ciclosporin levels. ... 

Therefore it seems that ciclosporin can greatly raise ezetimibe levels, possibly resulting in an increased effect on lipid reduction, and that ciclosporin levels can be raised, possibly significantly in some patients, by ezetimibe. If concurrent use is necessary, until the effects of concurrent treatment are better established, it would seem prudent to monitor both ciclosporin levels and the effects on lipid levels, anticipating the need to reduce the dosage of either drug. The authors of the case report cited sug-... 

Ezetimibe can be added to a statin to improve the concentrations of atherogenic hpopro-teins in patients who have undergone organ transplantation and who are taking ciclosporin. The addition of ezetimibe did not increase the frequency of adverse... 

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