Chryseomonas luteola

From Chryseomonas luteola in addition to chrysobactin a derivative (chrysomonin) was isolated where C-6 of the DHB unit is substituted with the N-atom of a pyridinium cation. Chrysomonin could be synthesized from chrysobactin (la). 

Very recently, new bacterial epoxide hydrolases have been described by Archer et al. [192], Janssen et al. [147,169], and Botes et al. [193]. Some of these studies led to results opposite to the ones predictable from the previous studies. Thus, the EH from Chryseomonas luteola displayed a good activity toward terminal olefins, whereas 2-substituted derivatives were bad substrates (Fig. 17). 

Fig. 17. Bacterial epoxide hydrolase. Resolution of ( )-l-methyl-l,2-epoxycyclohexane [192] and ( )-l,2-epoxyoctane [193] using respectively whole cells of Corynebacterium C12 and Chryseomonas luteola...

Small mono-substituted oxiranes bearing a halogen atom in its side chain such as compounds 1.2 and 1.3 have been hydrolyzed by mammalian and yeast epoxide hydrolases with very low enantioselectivity (E = 3 and 5.5, respectively). More recently, three red yeasts and one bacterial strain (Chryseomonas luteola [107]) have been reported to trans-... 

It must be stressed that all microorganisms reported to show preparatively useful epoxide hydrolase activity so far belong to safety class I, except Chryseomonas luteola, which is class II. The latter strains are known to cause ear infections in infants. 

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