Chronic wasting disease strains

Fig. 20 Fluorescent images of prion deposits associated with distinct prion strains, murine chronic wasting disease (mCWD) (a) and murine sheep scrapie (mSS) (b), which has been stained by PTAA. (c) Correlation diagram of the ratios, R532/639 and R532/ max, of the intensity of the emitted light from PTAA bound to prion deposits originating from individual mice infected with CWD (black symbols) or sheep scrapie (purple symbols) [35]...

Despite steady progress in non-bioassay discrimination of prion strains, the mouse bioassays remain superior. This was recently demonstrated when two strains of chronic wasting disease (CWD), a prion disease affecting cervids, with biochemically indistinguishable PrPSc aggregates, were recognized as separate CWD-1 and... 

Raymond GJ, Raymond LD, Meade-White KD et al (2007) Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice evidence for strains. J Virol 81 4305 1314... 

Sigurdson CJ, Manco G, Schwarz P, Liberski P, Hoover EA, Homemann S, Polymenidou M, Miller MW, Glatzel M, Aguzzi A (2006) Strain fidelity of chronic wasting disease upon murine adaptation. J Virol 80 12303-12311... 

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