Chronic myelogenous leukemia blast crisis

Sawyers CL, Hochhaus A, Feldman E et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis results of a phase II study. B/ooc/2002 99 3530-3539. 

Larghero J, Leguay T, Mourah S et al. Relationship between elevated levels of the alpha 1 acid glycoprotein in chronic myelogenous leukemia in blast crisis and pharmacological resistance to imatinib (Gleevec) in vitro and in vivo. Biochem Pharmacol 2003 66 1907-1913. 

Cortes J, Guilhot F, Rosti Get al. Dasatinib (SPRYCEL) in patients (pts) with chronic myelogenous leukemia in aeeelerated phase (AP-CML) that is imatinib-resistant (TM-R) or intolerant (IM-I) updated results of the CA180-005 START-A phase 11 study (Abstract 2160). Blood 2006 108 613a. Cortes J, Rousselot R Kim DW et al. Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis. Blood 2007 109 3207-3213. 

Neviani P, Santhanam R, Oaks JJ, Hiring AM, Notari M, Blaser BW, et al. FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia. J. Clin. Invest. 2007 117 2408-2421. 

Kouides PA, Rowe JM. A dose intensive regimen of cytosine arabinoside and daunorubicin for chronic myelogenous leukemia in blast crisis. Leuk Res 1995 19(10) 763-70. 

Chronic myelogenous leukemia may progress through several clinical phases. Most patients are diagnosed with CML in chronic phase. CML may then progress to accelerated phase and finally to blast crisis (either lymphoid or myeloid), which resembles acute leukemia and may be difficult to treat. 

Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the bcr-abl tyrosine kinase in the blast crisis of chronic myelogenous leukemia and acute lymphocytic leukemia with the Philadelphia chromosome. NEngl J Med 2001 344 1038-1042. 

Leis J, Stepan D, Curtin P, Ford J, Peng B, Schubach S, Druker B, Maziarz R. Central Nervous System Failure in Patients with Chronic Myelogenous Leukemia Lymphoid Blast Crisis and Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia and Lymphoma 2004 Treated with Imatinib (STI-571). Leukemia- Lymphoma 2004 45(4) 695-698. 

Daley GQ, Van Etten RA, Baltimore D. Blast crisis in a murine model of chronic myelogenous leukemia. Proc Natl Acad Sci USA. 1991 88 11336-8. 

M. Yoshimura, A. Nishikawa, Y. Ihara, T. Nishiura, H. Nakao, Y. Kanayama, Y. Matu-2awa, N. Taniguchi, High expression of UDP-N-acetylglucosamine beta-D mannoside beta-1,4-N-acetylglucosaminyltransferase III (GnT-111) in chronic myelogenous leukemia in blast crisis, Int J Cancer, 1995, 60, 443-449. 

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