Chromosomes ciprofloxacin

The continued evolution of the class is exemplified by the recent report of the ability of a variant of AAC(6 )-Ib, AAC(6 )-Ib-cr, to modify the synthetic fluoroquinolone antibiotic ciprofloxacin (Scheme 3.2.). ° Substrate plasticity may be a general hallmark of the GNAT class and this could help to explain the plethora of these genes in clinical strains and in bacterial chromosomes alike. 

D. Ciprofloxacin is a fluoroquinolone antibiotic that will inhibit the strand-cutting function of A subunit of DNA gyrase, a bacterial topoi-somerase II that introduces negative supercoils ahead of the rephcation fork. This disrupts DNA replication and repair, transcription, bacterial chromosome separation, and other bacterial processes involving DNA. At much higher concentrations, the type II topoisomerases of eukaryotic cells can be inhibited. 

Ciprofloxacin 247 is used to treat or prevent certain bacterial infections. Compound 247 is also used to treat or prevent anthrax in people who may have been exposed to anthrax germs in the air. Its mode of action depends upon blocking bacterial DNA replication by binding itself to an enzyme called DNA gyrase, and causing double-stranded breaks in the bacterial chromosome. 

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