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Chromatography, general improving separations

The application of pressure to the liquid phase in liquid chromatography generally increases the separation (see HPLC). Also in PIC improved efficiency of the column is observed if pressure is applied to the mobile phase (Wittmer, Nuessle and Haney Anal Chem 47 1422 1975). [Pg.21]

Most separations in liquid chromatography are performed at room temperature for convenience and because ambient temperatures provide reasonable column efficiency for low molecular mass solutes. Elevated temperatures are commonly used in ion-exchange chromatography to improve mass transfer kinetics and in size-exclusion chromatography to provide adequate solubility for polymers in useful mobile phases. Wider interest in temperature control and high-temperature separations in general results from improved precision of retention measurements (section 1.1.1), greater column efficiency (section 1.5.2), the use of temperature as a variable for method development (section 4.4.4), and shorter separation times due to the more favorable use of the column inlet pressure [70,71]. [Pg.449]

See other pages where Chromatography, general improving separations is mentioned: [Pg.69]    [Pg.1031]    [Pg.233]    [Pg.90]    [Pg.1031]    [Pg.69]    [Pg.166]    [Pg.186]    [Pg.24]    [Pg.70]    [Pg.142]    [Pg.1031]    [Pg.69]    [Pg.304]    [Pg.1326]    [Pg.270]    [Pg.172]    [Pg.144]    [Pg.90]    [Pg.58]    [Pg.228]    [Pg.197]    [Pg.216]    [Pg.24]    [Pg.94]    [Pg.9]    [Pg.4803]    [Pg.4804]    [Pg.1560]    [Pg.123]    [Pg.127]    [Pg.492]    [Pg.640]    [Pg.1254]    [Pg.267]    [Pg.835]    [Pg.835]    [Pg.75]    [Pg.241]    [Pg.179]    [Pg.62]    [Pg.358]    [Pg.56]    [Pg.133]   
See also in sourсe #XX -- [ Pg.34 , Pg.35 , Pg.36 , Pg.37 , Pg.38 , Pg.39 ]



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